Numerous from the phenotypes presented in Fig. 2 had been examined during the context of protease-activated receptor activation by thrombin or PAR4-AP. Whilst our info exposed altered outside the house-in signaling in unstimulated platelets, many scientific studies have supplied proof for agonist-induced enhancement of FAK and ERK signaling in platelets and cells expressing the human Pro33 integrin β

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To better fully grasp the molecular mechanisms by which this sequence variation modifies platelet perform, we produced transgenic knockin mice expressing a Pro32Pro33 integrin β

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3 in unstimulated platelets. Platelets had been isolated from WT and KI mice, and baseline plasma membrane expression of α

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